High Content Screening System

Since its first introduction more than a decade ago high content imaging systems have continually evolved with many improvements enabled to meet user demands of greater flexibility and the growing requirements of assays involving complex cellular disease models.

High content screening system.

Designed for researchers looking to increase their screening throughput the platform offers common excitation wavelengths for fluorescence and white light illumination for colorimetric samples. High content screening hcs is a well established approach for the multiparametric analysis of cellular events. Drawing on over a decade of experience with the industry leading opera and opera phenix system the opera phenix plus is designed for high throughput high content assays phenotypic screening assays using complex disease models such as live cells. Opera phenix high content screening system.

Hcs is also used to discover and optimize new drug candidates. However hescs require immunofluorescence staining with stemness markers e g oct 4 prior to hcs which can be time consuming and labor intensive in this study we employed transgenic hescs with enhanced green fluorescent protein driven by stemness gene oct 4. Our systems for high content imaging hci and high content analysis hca provide flexible scalability making it easy to evolve your system alongside your research. High content screening hcs in cell based systems uses living cells as tools in biological research to elucidate the workings of normal and diseased cells.

An end to end solution for high content imaging and analysis. The opera phenix plus high content screening system is the premier confocal solution for today s most demanding high content applications. Perkin elmer the opera phenix plus high content screening system is designed for fast response analysis of physiologically relevant model systems which adds fast frame rate image capture for. Explore our high content screening platforms that are designed to provide exceptional resolution for subcellular detection automated detection and phenotyping with intact fixed or live cells.

Our high content confocal imaging systems based on the csu are the ideal solution for drug screening using elaborated 3d and live cell assay systems as well as 2d fixed samples. High content screening hcs systems can be used for high throughput screening of drugs in human embryonic stem cells hescs. User friendly high content analysis software cellpathfinder with its versitile functionalities powerfully supports the analysis of various phnotype changes and target. With the compact and powerful cellinsight cx5 high content screening platform you can read and analyze a 96 well plate in under four minutes.

However one of the main problems arising from this approach is spectral crosstalk which can limit assay sensitivity.